Antipyretics and empiric therapy (e.g., antibiotics, glucocorticoids) should be avoided, if feasible, to prevent mas king clinical findings and delaying the diagnosis even further. In a significant number of patients, the underlying etiology remains undiagnosed. If the diagnosis remains unknown, additional laboratory studies (e.g., serology, electrophoresis) and advanced diagnostics (e.g., PET-CT, tissue biopsy) should be considered. The initial diagnostic approach to FUO should focus on a comprehensive history and physical examination with minimal initial diagnostics to identify diagnostic clues that can guide targeted diagnostics. Infections, malignancy, and inflammatory or rheumatic conditions are the most frequent etiologies of FUO. Fever of unknown origin (FUO) is defined as a temperature of > 38.3☌ (100.9☏) lasting for > 3 weeks with no clear etiology despite appropriate diagnostics.
0 kommentar(er)
